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1

Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase

Richard T. Eastman, John White, Oliver Hucke, Kohei Yokoyama, Christophe L.M.J. Verlinde, Michael A. Hast, Lorena S. Beese, Michael H. Gelb, Pradipsinh K. Rathod, Wesley C. Van Voorhis

Journal:

Molecular and Biochemical Parasitology

Year:

2007

Language:

english

File:

PDF, 313 KB

english, 2007

2

Regulation of mammalian aspartate-4-decarboxylase: Its possible role in oxaloacetate and energy metabolism

Pradipsinh K. Rathod, Jack H. Fellman

Journal:

Archives of Biochemistry and Biophysics

Year:

1985

Language:

english

File:

PDF, 480 KB

english, 1985

3

Antimalarial Agents Directed at Thymidylate Synthase

PRADIPSINH K. RATHOD

Journal:

Journal of Pharmacy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 501 KB

english, 1997

4

Kinetics and Ligand-Binding Preferences of Mycobacterium tuberculosis Thymidylate Synthases, ThyA and ThyX

Hunter, Joshua H., Gujjar, Ramesh, Pang, Cullen K. T., Rathod, Pradipsinh K., Abraham, Edathara

Journal:

Year:

2008

Language:

english

File:

PDF, 508 KB

english, 2008

5

Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase

Cullen K.T. Pang, Joshua H. Hunter, Ramesh Gujjar, Ramulu Podutoori, Julie Bowman, Devaraja G. Mudeppa, Pradipsinh K. Rathod

Journal:

Molecular and Biochemical Parasitology

Year:

2009

Language:

english

File:

PDF, 1.06 MB

english, 2009

6

Gene organization of a Plasmodium falciparum serine hydroxymethyltransferase and its functional expression in Escherichia coli

Suad Alfadhli, Pradipsinh K Rathod

Journal:

Molecular and Biochemical Parasitology

Year:

2000

Language:

english

File:

PDF, 1.43 MB

english, 2000

7

NIH Public Access

Phillips, Margaret A, Gujjar, Ramesh, Malmquist, Nicholas A, White, John, El, Farah, Baldwin, Jeffrey, Rathod, Pradipsinh K

Year:

2009

Language:

english

File:

PDF, 1.39 MB

english, 2009

8

Microfluidic approaches to malaria pathogenesis

Meher Antia, Thurston Herricks, Pradipsinh K. Rathod

Journal:

Cellular Microbiology

Year:

2008

Language:

english

File:

PDF, 246 KB

english, 2008

9

Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates

Shaw-Saliba, Kathryn, Clarke, David, Santos, Jorge M., Menezes, Maria José, Lim, Caeul, Mascarenhas, Anjali, Chery, Laura, Gomes, Edwin, March, Sandra, Bhatia, Sangeeta N., Rathod, Pradipsinh K., Ferr

Journal:

International Journal for Parasitology

Year:

2016

Language:

english

File:

PDF, 722 KB

english, 2016

10

Plasmodium falciparum:Direct Cloning and Expression of Pyrimethamine-Sensitive and Pyrimethamine-Resistant Dihydrofolate Reductase Domains

Mohammad Hekmat-Nejad, Pei-Chieh Lee, Pradipsinh K. Rathod

Journal:

Experimental Parasitology

Year:

1997

Language:

english

File:

PDF, 104 KB

english, 1997

11

Malaria-attributed death rates in India

Ashwani Kumar, Virendra Kumar Dua, Pradipsinh K Rathod

Journal:

Year:

2011

Language:

english

File:

PDF, 50 KB

english, 2011

12

A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells

Herricks, Thurston, Seydel, Karl B., Turner, George, Molyneux, Malcolm, Heyderman, Robert, Taylor, Terrie, Rathod., Pradipsinh K.

Journal:

Year:

2011

Language:

english

File:

PDF, 324 KB

english, 2011

13

Microfluidic Modeling of Cell−Cell Interactions in Malaria Pathogenesis

Antia, Meher, Herricks, Thurston, Rathod, Pradipsinh K.

Journal:

Year:

2007

Language:

english

File:

PDF, 434 KB

english, 2007

14

Plasmodium yoelii: Oral delivery of 5-fluoroorotate to treat malaria in mice

Pradipsinh K. Rathod, Zaida M. Gomez

Journal:

Experimental Parasitology

Year:

1991

Language:

english

File:

PDF, 209 KB

english, 1991

15

Response from Haldar, Lauer and Rathod

Kasturi Haldar, Sabine A. Lauer, Pradipsinh K. Rathod

Journal:

Trends in Microbiology

Year:

1997

Language:

english

File:

PDF, 200 KB

english, 1997

16

Identification of a Plasmodium falciparum histone 2A gene

Kathleen A. Creedon, David C. Kaslow, Pradipsinh K. Rathod, Thomas E. Wellems

Journal:

Molecular and Biochemical Parasitology

Year:

1992

Language:

english

File:

PDF, 192 KB

english, 1992

17

Estimating physical splenic filtration of Plasmodium falciparum-infected red blood cells in malaria patients

Thurston Herricks, Karl B. Seydel, Malcolm Molyneux, Terrie Taylor, Pradipsinh K. Rathod

Journal:

Cellular Microbiology

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

18

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications

Guler, Jennifer L., Freeman, Daniel L., Ahyong, Vida, Patrapuvich, Rapatbhorn, White, John, Gujjar, Ramesh, Phillips, Margaret A., DeRisi, Joseph, Rathod, Pradipsinh K., Su, Xin-zhuan

Journal:

Year:

2013

Language:

english

File:

PDF, 1.85 MB

english, 2013

19

Enhanced ex vivo Plasmodium vivax intraerythrocytic enrichment and maturation for rapid and sensitive parasite growth assays

Rangel, Gabriel W., Clark, Martha A., Kanjee, Usheer, Lim, Caeul, Shaw-Saliba, Kathryn, Menezes, Maria José, Mascarenhas, Anjali, Chery, Laura, Gomes, Edwin, Rathod, Pradipsinh K., Ferreira, Marcelo U

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2018

Language:

english

File:

PDF, 1.72 MB

english, 2018

20

Shotgun DNA microarrays and stage-specific gene expression in Plasmodium falciparum malaria

Rhian E. Hayward, Joseph L. DeRisi, Suad Alfadhli, David C. Kaslow, Patrick O. Brown, Pradipsinh K. Rathod

Journal:

Molecular Microbiology

Year:

2000

Language:

english

File:

PDF, 311 KB

english, 2000

21

Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase

Devaraja G. Mudeppa, Cullen K.T. Pang, Takafumi Tsuboi, Yaeta Endo, Fredrick S. Buckner, Gabriele Varani, Pradipsinh K. Rathod

Journal:

Molecular and Biochemical Parasitology

Year:

2007

Language:

english

File:

PDF, 387 KB

english, 2007

22

Atovaquone Tolerance in Plasmodium falciparum Parasites Selected for High-Level Resistance to a Dihydroorotate Dehydrogenase Inhibitor

Guler, Jennifer L., White, John, Phillips, Margaret A., Rathod, Pradipsinh K.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 418 KB

english, 2015

23

A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal Antifolates

Ganesan, Karthikeyan, Ponmee, Napawan, Jiang, Lei, Fowble, Joseph W., White, John, Kamchonwongpaisan, Sumalee, Yuthavong, Yongyuth, Wilairat, Prapon, Rathod, Pradipsinh K., Kim, Kami

Journal:

Year:

2008

Language:

english

File:

PDF, 509 KB

english, 2008

24

Bioisosteric Transformations and Permutations in the Triazolopyrimidine Scaffold To Identify the Minimum Pharmacophore Required for Inhibitory Activity against Plasmodium falciparum Dihydroorotate Dehydrogenase

Marwaha, Alka, White, John, El_Mazouni, Farah, Creason, Sharon A, Kokkonda, Sreekanth, Buckner, Frederick S., Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.21 MB

english, 2012

25

The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N -phenylbenzamide inhibitor reveals novel binding-site interactions

Deng, Xiaoyi, Matthews, David, Rathod, Pradipsinh K., Phillips, Margaret A.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Year:

2015

Language:

english

File:

PDF, 1.17 MB

english, 2015

26

Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase

Cullen K.T. Pang, Surya Kanta De, John White, Frederick S. Buckner, Gabriele Varani, Pradipsinh K. Rathod

Journal:

Molecular and Biochemical Parasitology

Year:

2005

Language:

english

File:

PDF, 155 KB

english, 2005

27

Extraâchromosomal DNA amplicons in antimalarial resistant Plasmodium falciparum

McDaniels, Jennifer M., Huckaby, Adam C., Carter, Sabrina A., Lingeman, Sabrina, Francis, Audrey, Congdon, Molly, Santos, Webster, Rathod, Pradipsinh K., Guler, Jennifer L.

Journal:

Molecular Microbiology

Year:

2020

File:

PDF, 7.77 MB

2020

28

Plasmodium falciparum:Kinetic Interactions of WR99210 with Pyrimethamine-Sensitive and Pyrimethamine-Resistant Dihydrofolate Reductase

Mohammad Hekmat-Nejad, Pradipsinh K. Rathod

Journal:

Experimental Parasitology

Year:

1997

Language:

english

File:

PDF, 188 KB

english, 1997

29

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection

Suresh M. Ganesan, Joanne M. Morrisey, Hangjun Ke, Heather J. Painter, Kamal Laroiya, Margaret A. Phillips, Pradipsinh K. Rathod, Michael W. Mather, Akhil B. Vaidya

Journal:

Molecular and Biochemical Parasitology

Year:

2011

Language:

english

File:

PDF, 497 KB

english, 2011

30

DNA microarrays for malaria

Pradipsinh K. Rathod, Karthikeyan Ganesan, Rhian E. Hayward, Zbynek Bozdech, Joseph L. DeRisi

Journal:

Trends in Parasitology

Year:

2002

Language:

english

File:

PDF, 120 KB

english, 2002

31

Variations in Frequencies of Drug Resistance in Plasmodium falciparum

Pradipsinh K. Rathod, Tara McErlean and Pei-Chieh Lee

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 777 KB

english, 1997

32

Topoisomerase II from Human Malaria Parasites

Mudeppa, Devaraja G., Kumar, Shiva, Kokkonda, Sreekanth, White, John, Rathod, Pradipsinh K.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 1.90 MB

english, 2015

33

Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265

White, John, dhingra, satish, Deng, Xiaoyi, El Mazouni, Farah, Lee, Marcus, Afanador, Gustavo, Lawong, Aloysus, Tomchick, Diana R, Ng, Caroline L., Bath, Jade, Rathod, Pradipsinh K, Fidock, David A, P

Journal:

ACS Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 2.11 MB

english, 2018

34

Improved light microscopy counting method for accurately counting Plasmodium parasitemia and reticulocytemia

Lim, Caeul, Pereira, Ligia, Shardul, Pritish, Mascarenhas, Anjali, Maki, Jennifer, Rixon, Jordan, Shaw-Saliba, Kathryn, White, John, Silveira, Maria, Gomes, Edwin, Chery, Laura, Rathod, Pradipsinh K.,

Journal:

American Journal of Hematology

Year:

2016

Language:

english

File:

PDF, 716 KB

english, 2016

35

Heterologous expression in Toxoplasma gondii reveals a topogenic signal anchor in a Plasmodium apicoplast protein

Narayan, Aishwarya, Mastud, Pragati, Thakur, Vandana, Rathod, Pradipsinh K., Mohmmed, Asif, Patankar, Swati

Journal:

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

36

Regulatory Hotspots in the Malaria Parasite Genome Dictate Transcriptional Variation

Gonzales, Joseph M., Patel, Jigar J., Ponmee, Napawan, Jiang, Lei, Tan, Asako, Maher, Steven P., Wuchty, Stefan, Rathod, Pradipsinh K., Ferdig, Michael T., Templeton, Thomas J.

Journal:

Year:

2008

Language:

english

File:

PDF, 422 KB

english, 2008

37

Deformability limits of Plasmodium falciparum-infected red blood cells

Thurston Herricks, Meher Antia, Pradipsinh K. Rathod

Journal:

Cellular Microbiology

Year:

2009

Language:

english

File:

PDF, 821 KB

english, 2009

38

Prized malaria drug target nailed

Rathod, Pradipsinh K., Phillips, Margaret A.

Journal:

Natural Structural Biology

Year:

2003

Language:

english

File:

PDF, 686 KB

english, 2003

39

Plasmodium Dihydroorotate Dehydrogenase: A Promising Target for Novel Anti-Malarial Chemotherapy

A. Phillips, Margaret, K. Rathod, Pradipsinh

Journal:

Infectious Disorders - Drug Targets(Formerly Current Drug Targets - Infectious Disorders)

Year:

2010

Language:

english

File:

PDF, 585 KB

english, 2010

40

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

Deng, Xiaoyi, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, Burrows, Jeremy N., Kaminsky, Werner, Charman, Susan A., Matthews, David, Rathod, Pradipsinh K., Phillips, Margaret A.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.84 MB

english, 2014

41

Anopheles subpictus carry human malaria parasites in an urban area of Western India and may facilitate perennial malaria transmission

Kumar, Ashwani, Hosmani, Rajeshwari, Jadhav, Shivaji, de Sousa, Trelita, Mohanty, Ajeet, Naik, Milind, Shettigar, Adarsh, Kale, Satyajit, Valecha, Neena, Chery, Laura, Rathod, Pradipsinh K.

Journal:

Malaria Journal

Year:

2016

Language:

english

File:

PDF, 1.80 MB

english, 2016

42

Indispensable malaria genes

White, John, Rathod, Pradipsinh K.

Journal:

Year:

2018

Language:

english

File:

PDF, 779 KB

english, 2018

43

A coupled radiometric assay for dihydrofolate reductase based on the oxidative decarboxylation of d-6-phospho-[1-14C]gluconate

Pradipsinh K. Rathod, Philip Reyes

Journal:

Analytical Biochemistry

Year:

1983

Language:

english

File:

PDF, 447 KB

english, 1983

44

Analysis of Flavin Oxidation and Electron-Transfer Inhibition in Plasmodium falciparum Dihydroorotate Dehydrogenase †

Malmquist, Nicholas A., Gujjar, Ramesh, Rathod, Pradipsinh K., Phillips, Margaret A.

Journal:

Year:

2008

Language:

english

File:

PDF, 274 KB

english, 2008

45

A call to arms: Unifying the fight against resistance

Kaushansky, Alexis, Hedstrom, Lizbeth, Goldman, Aaron, Singh, Juswinder, Yang, Priscilla L., Rathod, Pradipsinh K., Cynamon, Michael, Wodarz, Dominik, Mahadevan, Daruka, Tomaras, Andrew, Navia, Manuel

Journal:

Science Signaling

Year:

2018

Language:

english

File:

PDF, 94 KB

english, 2018

46

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria Parasite Plasmodium falciparum

Phillips, Margaret A., Gujjar, Ramesh, Malmquist, Nicholas A., White, John, El Mazouni, Farah, Baldwin, Jeffrey, Rathod, Pradipsinh K.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 531 KB

english, 2008

47

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

Philip Reyes, Pradipsinh K. Rathod, Donald J. Sanchez, John E.K. Mrema, Karl H. Rieckmann, Hans-G. Heidrich

Journal:

Molecular and Biochemical Parasitology

Year:

1982

Language:

english

File:

PDF, 953 KB

english, 1982

48

Stochastic versus stable transcriptional differences on Plasmodium falciparum DNA microarrays

Karthikeyan Ganesan, Lei Jiang, Pradipsinh K. Rathod

Journal:

International Journal for Parasitology

Year:

2002

Language:

english

File:

PDF, 324 KB

english, 2002

49

Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein–protein interactions

Kumar, Shiva, Krishnamoorthy, Kalyanaraman, Mudeppa, Devaraja G., Rathod, Pradipsinh K.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Year:

2015

Language:

english

File:

PDF, 1.50 MB

english, 2015

50

Malaria in India: The Need for New Targets for Diagnosis And Detection of Plasmodium vivax

Patankar, Swati, Sharma, Shobhona, Rathod, Pradipsinh K., Duraisingh, Manoj

Journal:

PROTEOMICS - Clinical Applications

Year:

2017

Language:

english

File:

PDF, 794 KB

english, 2017

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